Celiac disease (also known as gluten-intolerance) is a disorder that involves a chronic immunologic reaction to the gluten contained in some cereal grains. This reaction causes destruction of villi, the tiny, fingerlike protrusions lining the small intestine, resulting in malabsorption of nutrients.
Disease symptoms include diarrhoea, abdominal bloating, weight loss, , malnutrition and skin reactions. Diagnosis based on the detection of antibodies is rather accurate. It is worth mentioning that current guidelines like from the “American College of Gastroenterology” indicate that IgA anti-tTG detection remains the first choice marker for diagnosing coeliac disease in patients aged over 2 years old.